Structural studies of macromolecules: biocrystallography and diffractometry


Content

  • Principles of protein structure
  • Classification of protein folds
  • Protein handling and crystallization
  • Modern diffraction techniques
  • Phasing methods in protein crystallography
  • Electron density maps and model building
  • Protein Data Bank (PDB) and validation of protein models
  • www.man.poznan.pl/CBB/CWICZENIA/CHEM/index.html

Aims

Familiarize the students with the principles of protein structure, properties of proteins and their crystals, the crystallographic method of macromolecular structure determination, and with the global resources of biostructural information.

Learning outcomes

The students will be able to:

  • find and use the information about the structure of biological macromolecules available in databanks
  • assess the quality of macromolecular models
  • use computer graphics for macromolecular structure analysis
  • understand the principles of protein crystallization and of macromolecular structure determination by X-ray diffraction

Recommended Books

  • G. Rhodes, Crystallography Made Crystal Clear, Academic Press, New York 2007
  • C. Branden, J. Tooze, Introduction to Protein Structure, Garland Publishing, New York 1998

 

Teaching Staff

Mariusz Jaskólski

Hours

Lecture: 15 h
Practical courses: 30 h

Grading System

Written multiple-choice test

About SERP-Chem

Since its creation in 2008 the SERP-Chem master has benefit from the support of many patners. Click on the following link to visit our partners.

This project has been funded with support from the European Commission. This communication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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  • Phone:
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  • Email:
    serp.chem@u-psud.fr
  • Address:
    Université Paris-Sud
    Building 308 (room 3016, 1st floor)
    91 405 ORSAY cedex - FRANCE

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